Development of Multi-target therapy for Alzheimer’s disease using human neural crest-derived stem cells
J. Y. Lim, J. E. Lee, S. H. Yang, H. K. Lim, S. W. Kim
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AbstractStem cell transplantation is a promising therapeutic strategy for the treatment of many neurological disorders. The therapeutic effects, however, are sometimes inconsistent and unpredictable. Human neural crest-derived nasal turbinate stem cells (hNTSCs) are an excellent alternative source of adult stem cells for clinical use because they can be obtained easily by minimally invasive collection procedures and expanded rapidly ex vivo for transplantation. Moreover, the characteristics of hNTSCs, including their proliferation, differentiation, and immunophenotype, are not affected by donor age or passage number (Hwang et al., 2013), while other kinds of stem cells exhibit age and passage-related reduction in multiple characteristics.Keywords: Alzheimer’s disease, human brain organoid, hNTSCs, cell transplantation, 5 × FAD mice
J. Y. Lim, J. E. Lee, S. H. Yang, H. K. Lim, S. W. Kim (2022). Development of Multi-target therapy for Alzheimer’s disease using human neural crest-derived stem cells. Gerontechnology, 21(s),1-1
https://doi.org/10.4017/gt.2022.21.s.822.sp3