Drug repositioning for a potential drug to prevent muscle wasting in aged mice
Y.-I. Lee
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AbstractMuscle wasting, resulting from aging or pathological conditions, leads to reduced quality of life, increased morbidity, and increased mortality. Much research effort has been focused on the development of exercise mimetics to prevent muscle atrophy and weakness. In this study, we identified indoprofen from a screen for peroxisome proliferator-activated receptor γ coactivator α (PGC-1α) inducers and report its potential as a drug for muscle wasting.Keywords: exercise mimetic, hypertrophic response, indoprofen, muscle wasting, muscle weakness, PDK1
Y.-I. Lee (2022). Drug repositioning for a potential drug to prevent muscle wasting in aged mice. Gerontechnology, 21(s),3-3
https://doi.org/10.4017/gt.2022.21.s.808.3.sp3