Systems biology of human microbiome for the prediction of Alzheimer's disease prognosis
S. J. Lee, K. H. Lee
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AbstractThere are numerous microorganisms dwelling on various parts of our body. The community of those microorganisms has been called microbiome, regarded as our “second genome”. Since birth, microbiome composition changes through lifespan and influences host human physiology. In older adults, an imbalance of the gut microbiome has been reported to initiate harmful inflammation (Ragonnaud and Biragyn, 2021). There have been increasing amounts of evidence that dysbiotic microbiome could lead to neurodegenerative diseases. In Alzheimer’s disease cases, treatment with prebiotic supplements improved AD-like symptoms and shifted the levels of associated biomarkers (Arora et al, 2020). In this presented study, we initiated the in-depth shotgun metagenome study with GARD elderly cohort data. We aim to specify causal microbiome strain associated with AD onset, subsequent screening kit development, and to invent AD-preventing probiotics.Keywords: human microbiome, shotgun metagenome, Alzheimer’s disease
S. J. Lee, K. H. Lee (2022). Systems biology of human microbiome for the prediction of Alzheimer's disease prognosis. Gerontechnology, 21(s),5-5
https://doi.org/10.4017/gt.2022.21.s.821.5.sp3