Plasma oligomeric beta-amyloid is associated with cerebral beta-amyloid deposition in cognitively normal older adults
S.-M. Wang, D. W. Kang, Y. H. Um, N.-Y. Kim, H. K. Lim
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AbstractExploration of Alzheimer’s disease (AD) pathology by investigating beta-amyloid, tau, and neurodegeneration are effective in detecting AD at its preclinical phase. However, PET imaging of amyloid, tau, and FDG requires high cost whereas cerebrospinal fluid studies of Aβ42, phosphorylated tau, and total tau are invasive. Beta-amyloid (Aβ) is formed when beta-amyloid precursor protein (APP) is cleaved by beta- and gamma-secretase. Among diverse Aβs, Oligomerized Aβ (OAβ) is known to be the most toxic and is strongly associated with the earlier pathogenesis of AD. Multiple validation studies showed that the Multimer Detection System-Oligomeric Aβ (MDS-OAβ) technique can measure the oligomerization dynamics of Aβ in a plasma sample. We aimed to investigate whether MDS-OAβ can reflect cerebral Aβ deposition in cognitively normal older adults.Keywords: amyloid beta deposition; plasma; oligomer, diagnosis, Alzheimer’s Disease
S.-M. Wang, D. W. Kang, Y. H. Um, N.-Y. Kim, H. K. Lim (2022). Plasma oligomeric beta-amyloid is associated with cerebral beta-amyloid deposition in cognitively normal older adults. Gerontechnology, 21(s),3-3
https://doi.org/10.4017/gt.2022.21.s.822.3.sp3